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Updated: Nov 6, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Unique Considerations for Complete Surgical Analgesia for Below-the-Knee Amputations
He Li1, David H Cho1, Vadim Tokhner1
1Department of Anesthesiology, Harbor-University of California, Los Angeles Medical Center, Torrance, USA.
The posterior femoral cutaneous nerve (PFCN) may significantly innervate the lower leg in some patients. Standard femoral and sciatic nerve blocks might be insufficient for below-knee amputation analgesia in these cases.
Area of Science:
- Anesthesiology
- Neuroscience
- Surgical Pain Management
Background:
- Cadaver studies suggest the posterior femoral cutaneous nerve (PFCN) innervates the posterior lower leg.
- Clinical relevance of PFCN innervation requires investigation in surgical patients.
Observation:
- A patient undergoing below-knee amputation (BKA) with femoral and sciatic nerve blocks experienced pain at posteromedial leg incisions.
- The patient reported adequate analgesia in other lower leg areas under monitored anesthesia care (MAC).
Findings:
- This case suggests a potential significant contribution of the PFCN to sensory innervation in a subset of patients.
- Standard peripheral nerve blocks (femoral and sciatic) may not provide complete surgical analgesia for BKA in these individuals.
Implications:
- Consideration of PFCN blockade may be necessary for adequate BKA analgesia in select patients.
- Further research is warranted to identify patients benefiting from PFCN blockade during BKA procedures.
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