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Updated: Nov 6, 2025

Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery
Justine Faramia1,2, Zheng Hao3, Michael B Mumphrey3
1Centre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec, QC, Canada.
Abstract:
Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching higher levels after biliopancreatic diversion with duodenal switch (BPD-DS) than after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This increase is closely associated with insulin sensitization. In mice and rats, BPD-DS and RYGB operations also increase circulating IGFBP-2 levels, which are not affected by SG or caloric restriction. In mice, Igfbp2 deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not affect long-term enhancement in glucose homeostasis. This study demonstrates that the modulation of circulating IGFBP-2 may play a role in the early improvement of insulin sensitivity and loss of adiposity brought about by bariatric surgery.
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