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Related Concept Videos

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

128
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
128

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Specialty-Specific Readmission Risk Models Outperform General Models in Estimating Hepatopancreatobiliary Surgery

Florence E Turrentine1,2, Timothy L McMurry2,3, Mark E Smolkin2,3

  • 1Department of Surgery, University of Virginia, Box 800709, Charlottesville, VA, 22908-0709, USA.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
|May 5, 2021
PubMed
Summary
This summary is machine-generated.

Specialty-specific readmission models for hepatopancreatobiliary (HPB) surgery patients significantly outperform general risk assessment tools. Developing targeted strategies based on these HPB models can help reduce costly patient readmissions.

Keywords:
ACS NSQIPHepatobiliary surgeryPancreatic surgeryReadmissionReadmission reductionReadmission risk prediction

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Area of Science:

  • Hepatopancreatobiliary (HPB) Surgery
  • Medical Informatics
  • Health Services Research

Background:

  • Readmissions pose significant financial and patient-related burdens in hepatopancreatobiliary (HPB) surgery.
  • Existing readmission prediction tools are not specifically designed or validated for the unique HPB patient population.

Purpose of the Study:

  • To develop and validate procedure-specific readmission risk models for pancreatectomy and hepatectomy patients.
  • To compare the performance of these novel specialty-specific models against existing general readmission risk tools.

Main Methods:

  • Developed subspecialty readmission risk assessments (SRRA) for pancreatectomy and hepatectomy using 2014-15 ACS NSQIP data.
  • Validated these SRRA models and six other general models in institutional cohorts (2013-2017) of HPB surgery patients.
  • Compared model performance using area under the receiver operating characteristic curves (AUC).

Main Results:

  • Specialty-specific readmission models demonstrated superior performance compared to general models.
  • The derived pancreatectomy SRRA achieved an AUC of 0.66, and hepatectomy SRRA achieved an AUC of 0.74.
  • Modified models like Readmission After Pancreatectomy (AUC=0.76) and Readmission Risk Score for hepatectomy (AUC=0.78) also outperformed general tools (e.g., LACE Index, ARIA).

Conclusions:

  • Readmission risk models tailored to HPB surgery subspecialties using 30-day data are more effective than general prediction tools.
  • Hospitals and surgical practices should implement specialty-specific readmission reduction strategies for HPB patients.