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Updated: Sep 17, 2026

14:43
Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
Published on: August 27, 2014
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Single-molecule determination of chemical equilibrium of DNA intercalation by electrical conductance
Lu Zhang1, Satoshi Kaneko1, Shintaro Fujii1
1Department of Chemistry, School of Science, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo 152-8551, Japan. tnishino@chem.titech.ac.jp.
Abstract:
We investigated a single-molecule reaction of DNA intercalation as an example of a bimolecular association reaction. Single-molecule conductance values of the product and reactant molecules adsorbed on an Au surface were measured to identify and quantify these molecules. The binding isotherm was constructed, and the association constant of the reaction was determined on a single-molecule basis.

