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Bioinspired self-degradable hydrogels towards wound sealing
Qingchen Cao1, Guofei Sun2, Xing Wang1
1Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. dcwu@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, China. wangxing@iccas.ac.cn.
Abstract:
Inspired by the autolysis of shaggy mane, we developed a self-degradable hydrogel as a medical adhesive for skin wounds. The rapid gelation and self-degradation of the hydrogel were achieved via the Michael addition and subsequent hydrolysis of the addition product. In vivo experiments further showed that the hydrogel adhesive was efficiently applied for skin wound repair.
