Versatile fluorinated Pd@Au nanoplates doped with yttrium for tumor theranostics

As one of the emerging modalities of magnetic resonance imaging (MRI), 19F MRI is highly conducive for the specific detection and imaging of deep-seated tumors, with negligible background. However, most 19F MRI probe designs are constructed with organic CF3, which contains rich fluorine atoms, and few of the fluorine-containing groups are equipped with therapeutic function. Herein, we designed a versatile 19F MRI-based theranostic nanoplatform, FY-Pd@Au nano-metallacages (FY-Pd@Au NCs), which not only serve as a 19F MRI/CT/PAI contrast agent, but also produce reactive oxygen species (ROS) by type I photodynamic therapy (PDT) pathway, as well as heat for photothermal therapy (PTT), under the single NIR laser irradiation. Overall, this work successfully built a theranostics nanoplatform based on 19F MRI.