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Hopelessness and Depression Predict Sarcopenia in Advanced CKD and Dialysis: A Multicenter Cohort Study
N Kurita1, T Wakita, S Fujimoto
1Noriaki Kurita, MD, PhD, Department of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan, Tel: +81-24-547-1471, Fax: +81-24-547-1468, E-mail: kuritanoriaki@gmail.com, (Twitter handle: @kuritanoriaki).
The Journal of Nutrition, Health & Aging
|May 5, 2021
Summary
Depression and hopelessness are linked to sarcopenia in chronic kidney disease (CKD) patients. Interventions targeting these mental health aspects may help prevent muscle loss in CKD.
Area of Science:
- Nephrology
- Geriatrics
- Psychiatry
Background:
- Chronic kidney disease (CKD) patients frequently experience depression and hopelessness.
- These psychological states are often linked to reduced physical activity.
- Sarcopenia, a loss of muscle mass, is a significant concern in CKD.
Purpose of the Study:
- To investigate the association between sarcopenia and depression/hopelessness in CKD patients.
- To quantify the relationship using validated questionnaires.
- To explore both cross-sectional and longitudinal links.
Main Methods:
- A multicenter cohort study in Japan with 314 CKD patients.
- Sarcopenia assessed using the SARC-F questionnaire at baseline and one year.
- Depression measured by the CES-D scale and hopelessness by the HR-Hope scale.
- Logistic regression models were employed for analysis.
Main Results:
- Baseline sarcopenia was observed in 28.3% of patients; 24.4% had sarcopenia at one year.
- Higher levels of hopelessness and depression were significantly associated with baseline sarcopenia.
- Both hopelessness and depression predicted incident sarcopenia at the one-year follow-up.
Conclusions:
- Hopelessness and depression are significant predictors of sarcopenia in CKD patients.
- Interventions aimed at alleviating depression and hopelessness may help prevent sarcopenia.
- Antidepressant therapies or educational programs could be beneficial.
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