Modulator effect of mangiferin on biochemical characterization in 7,12-dimethylbenz[a]anthracene induced oral cancer...

Area of Science:

• Natural Product Chemistry
• Cancer Chemoprevention
• Oral Oncology

Background:

• Oral cancer (OC) presents a significant health challenge, particularly in developing nations.
• Effective chemo-preventive strategies using less toxic, natural compounds are needed to combat OC.
• Tobacco and alcohol consumption are major risk factors for oral cancer.

Purpose of the Study:

• To evaluate the anticancer activity of mangiferin against chemically induced oral cancer.
• To assess the effects of mangiferin on antioxidant and detoxification enzyme levels.
• To investigate mangiferin's impact on lipid peroxidation and histopathological changes in oral cancer models.

Main Methods:

• Oral cancer was induced in hamsters using 7,12-dimethylbenz[a]anthracene (DMBA).
• Mangiferin was administered orally at a dosage of 50 mg/kg body weight.
• Antioxidant levels, lipid peroxidation, liver markers, and histopathological changes were analyzed.

Main Results:

• DMBA treatment led to significant oral cancer development, affecting body weight and tumor burden.
• Mangiferin treatment significantly prevented body weight loss and tumor progression.
• Mangiferin modulated antioxidant, anti-lipid peroxidation, and detoxification enzyme levels.

Conclusions:

• Mangiferin exhibits significant anti-carcinoma effects against DMBA-induced oral cancer in hamsters.
• Mangiferin acts as a modulator of key antioxidant and detoxification pathways.
• These findings support mangiferin's potential as a chemo-preventive agent for oral cancer.