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Lipid Digestion

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.

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Shotgun Lipidomics of Rodent Tissues

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

LipidSuite: interactive web server for lipidomics differential and enrichment analysis.

Ahmed Mohamed¹, Michelle M Hill^1,2

¹Precision & Systems Biomedicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.

Nucleic Acids Research

|May 5, 2021

Summary

LipidSuite is a new webserver that simplifies differential lipidomics data analysis. It provides a user-friendly, step-by-step workflow for preprocessing, exploration, and interpretation of lipidomics datasets, making complex analyses accessible.

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Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Area of Science:

Biochemistry
Bioinformatics
Computational Biology

Background:

High-throughput mass spectrometry enables comprehensive lipid profiling.
Analyzing and interpreting large lipidomics datasets remains a significant challenge.
Existing tools often lack integrated workflows for differential analysis and biological interpretation.

Purpose of the Study:

To present LipidSuite, an end-to-end web server for differential lipidomics data analysis.
To provide a user-friendly platform for preprocessing, exploration, differential, and enrichment analysis.
To facilitate the biological interpretation of untargeted and targeted lipidomics data.

Main Methods:

Developed a web server offering a step-by-step analysis workflow.
Accepted multiple input data formats (mwTab, Skyline CSV, numerical matrix) and experimental variables.
Implemented automated parsing of lipid names for class and chain length analysis, interactive data exploration, and statistical analyses (univariate, multivariate, unsupervised) with confounding variable adjustment.

Main Results:

LipidSuite supports preprocessing, exploration, differential analysis, and enrichment analysis.
The server allows interactive data subsetting and visualization.
Results are available for interactive viewing and download, supporting publication and reporting.

Conclusions:

LipidSuite offers a free, user-friendly solution to overcome challenges in differential lipidomics analysis.
The platform enhances the biological interpretation of lipidomics datasets.
It is expected to facilitate both initial analysis and re-analysis of lipidomics data.