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Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

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[Mass testing for Covid-19 : what can we learn from real-world implementation ?]

Yann Sancosme¹, Kevin Selby¹, Valérie D'acremont¹

¹Centre universitaire de médecine générale et santé publique, Unisanté, 1015 Lausanne.

Revue Medicale Suisse

|May 5, 2021

Summary

Mass testing for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) requires frequent, prolonged testing with high participation. Targeted screening using rapid tests is more practical for specific populations and events to control the pandemic.

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Area of Science:

Epidemiology
Public Health Policy

Background:

Modeling studies suggest mass testing for SARS-CoV-2 can be effective.
Real-world implementation data is limited for evaluating mass testing's pandemic control impact.

Purpose of the Study:

To evaluate the feasibility and effectiveness of mass testing strategies for SARS-CoV-2.
To identify optimal approaches for utilizing testing interventions in pandemic control.

Main Methods:

Review of existing modeling studies on mass testing.
Analysis of real-world implementation challenges and outcomes.
Assessment of rapid test utility for targeted screening.

Main Results:

Mass testing requires sustained high participation and frequent testing alongside public health measures.
Screening is more effective for targeted populations and high-risk events.
Rapid tests offer a cost-effective solution for these targeted interventions.

Conclusions:

Widespread, frequent mass testing for SARS-CoV-2 faces significant implementation hurdles.
Targeted screening using rapid diagnostic tests is a more pragmatic approach for specific settings.
Strategic use of rapid tests can aid in controlling SARS-CoV-2 transmission in defined high-risk environments.