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Related Experiment Video

Updated: Nov 6, 2025

Triplet Fusion Upconversion Nanocapsule Synthesis

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

Ultrasmall Downconverting Nanoparticle for Enhanced Cerenkov Imaging.

Qize Zhang^1,2,3, Edwin C Pratt^4,5, Ryo Tamura^1,4

¹Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.

|May 5, 2021

Summary

Europium oxide nanoparticles shift Cerenkov light to red for enhanced *in vivo* imaging. This breakthrough enables brighter, smaller radiolabeled nanoparticles for preclinical cancer diagnosis and multimodal imaging.

Keywords:

Cerenkov imaging europium ion exchange lanthanide nanomaterial oxidation state ultrasmall

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Last Updated: Nov 6, 2025

Triplet Fusion Upconversion Nanocapsule Synthesis

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Published on: September 7, 2022

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

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Published on: October 7, 2014

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

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Published on: August 30, 2017

Area of Science:

Nanotechnology
Medical Imaging
Radiochemistry

Background:

Cerenkov imaging uses radiotracers for optical approaches in nuclear imaging.
Cerenkov radiation is primarily UV/blue, limiting *in vivo* utility due to tissue absorption.

Purpose of the Study:

To develop a method for shifting Cerenkov light to the red spectrum for improved tissue penetration.
To create ultrasmall, bright, and radiolabeled europium oxide nanoparticles for preclinical cancer imaging.

Main Methods:

Synthesized square-shape europium oxide (Eu2O3) nanoparticles using a fluorescent down-conversion technique.
Functionalized nanoparticles with polyethylene glycol and performed chelate-free radiolabeling for intravenous injection.
Optimized synthesis with trimethylamine N-oxide to enhance particle brightness and reduce size.

Main Results:

Achieved a significant increase in nanoparticle brightness and synthesized the smallest radiolabeled europium-based nanoparticle to date.
Demonstrated the *in vivo* visualization of lymph nodes and tumors in mice using the developed nanoparticles.
Confirmed the potential for multimodal imaging capabilities.

Conclusions:

Europium oxide nanoparticles offer a promising strategy for red-shifting Cerenkov light, overcoming limitations of UV/blue emission.
The developed ultrasmall, bright, and radiolabeled Eu2O3 nanoparticles represent a novel preclinical platform for cancer diagnosis.
This approach expands the utility of radiotracers for optical imaging and multimodal cancer detection.