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Published on: August 24, 2019
Sedentary behavior is associated with chronic obstructive pulmonary disease: A generalized propensity score-weighted
Yalin Lei1, Kun Zou2,3,4, Junguo Xin5,6
1Department of Health-Related Social and Behavioral Sciences.
Sedentary behavior, defined as sitting for over 7 hours daily, is linked to a higher risk of developing chronic obstructive pulmonary disease (COPD). Reducing sitting time may be key for COPD prevention and public health.
Area of Science:
- Public Health
- Epidemiology
- Respiratory Medicine
Background:
- Chronic obstructive pulmonary disease (COPD) is a major global cause of mortality.
- Sedentary behavior is a known risk factor for respiratory diseases like asthma.
- The specific association between sedentary behavior and COPD risk remains unclear.
Purpose of the Study:
- To investigate the independent association between sedentary behavior and the risk of developing COPD.
- To quantify the risk of COPD associated with different durations of daily sedentary behavior.
Main Methods:
- Utilized data from the 2018 Sichuan Province Chronic Disease and Lifestyle Population Survey.
- Employed multivariable regression and generalized propensity score-weighted (GPSW) analysis to assess the association.
- Controlled for potential confounding factors, including smoking status.
Main Results:
- Individuals sedentary for >7 hours/day showed significantly higher COPD risk (OR=2.020, P<.001 in regression; OR=2.381, P<.001 in GPSW).
- A dose-response relationship was observed: >5 hours/day sedentary behavior increased COPD risk by 1.242 (GPSW) to 1.377 (sensitivity analysis) times.
- Findings remained significant after adjusting for confounders and in sensitivity analyses.
Conclusions:
- Sedentary behavior is independently associated with an increased risk of COPD.
- Reducing sedentary time may play a crucial role in COPD prevention strategies.
- These findings have significant implications for public health guidance and future research.
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