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Related Experiment Videos

Imipramine treatment and preference for sweets.

M H Fernstrom1, D J Kupfer

  • 1Department of Psychiatry, University of Pittsburgh, PA.

Appetite
|April 1, 1988
PubMed
Summary

Imipramine treatment can alter food preferences in depressed patients, with about a third reporting a desire for sweets. However, only 15% developed this preference during treatment, suggesting nuanced effects of antidepressants on appetite.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Nutritional Science

Background:

  • Antidepressant medications, such as imipramine, are widely used for treating depression.
  • Changes in appetite and food preference are common side effects of psychotropic medications.
  • Understanding these changes is crucial for patient adherence and overall treatment efficacy.

Purpose of the Study:

  • To investigate how imipramine treatment affects food preferences in patients with depression.
  • To differentiate between pre-existing food preferences and those that emerge during antidepressant therapy.

Main Methods:

  • A group of 40 depressed patients was assessed for food preference before and after 4 months of imipramine treatment.
  • The Pittsburgh Appetite Test was used to categorize self-reported food preferences based on nutrient and hedonic properties.
  • Individual responses were analyzed to identify changes in food choices.

Main Results:

  • After 4 months, 35% of patients reported a preference for high-carbohydrate, high-fat, sweet-tasting foods.
  • Of those with a new preference, 6 out of 14 (approximately 15% of the total cohort) developed this during imipramine treatment.
  • The remaining 65% of patients showed no significant changes in their food preferences.

Conclusions:

  • Approximately one-third of patients treated with imipramine may report a preference for sweets.
  • A smaller proportion, around 15%, actually develop this preference as a result of the medication.
  • These findings highlight the complex relationship between antidepressants and dietary choices, impacting treatment management.

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