Related Experiment Video
Updated: Aug 11, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Monascuslactams A-D, cytotoxic γ-lactams from marine fungus Monascus albidus BB3
Qi Guo1, Xiao-Ming Dai1, Wen-Jian Lan2
1School of Chemistry, Sun Yat-sen University, Guangzhou, People's Republic of China.
Abstract:
Amino acid-directed strategy becomes an efficient way to explore the alkaloids' biosynthetic potential of marine fungi. The metabolites of marine fungus Monascus albidus BB3 were regulated obviously when cultured in GPY medium supplemented with L-tryptophan, L-phenylalanine, D,L-methionine, L-threonine, L-lysine, L-serine and L-valine. Four new γ-lactams, monascuslactams A-D (1-4), together with two known compounds pulchellalactam (5) and O-acetylperlolyrine (6) were obtained. Their structures were determined by comprehensive analysis on the 1 D and 2 D NMR, HRESIMS, UV and IR data, and their absolute configurations were assigned by the experimental and calculated ECD data analysis. Compounds 3, 4 and 6 showed moderate cytotoxicity against human cancer cell lines SUNE1, HepG2, QGY7701, GLC82, HCT116 and MDA-MB-231.
Related Concept Videos
Bacterial Phylum Actinobacteria
Production of Antibiotics
Inhibitors of Gram-positive Cell Wall Synthesis
Antifungal Agents
Clinical Significance of Antibiotic Resistance

