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Hexachromatic bioinspired camera for image-guided cancer surgery.

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  • 1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Researchers developed a novel imaging sensor inspired by mantis shrimp vision for image-guided cancer surgery. This technology enhances tumor detection and surgical site mapping, improving patient outcomes.

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Area of Science:

  • Biomedical Engineering
  • Surgical Technology
  • Bio-inspired Imaging

Background:

  • Cancer surgery requires precise tumor removal and metastasis identification.
  • Current surgical guidance methods have limitations in visualizing cancerous tissues.
  • The mantis shrimp visual system offers a unique model for advanced imaging.

Purpose of the Study:

  • To develop a bio-inspired image sensor for enhanced image-guided surgery.
  • To integrate color and near-infrared (NIR) fluorescence imaging capabilities.
  • To improve visualization of tumors and surgical site topography.

Main Methods:

  • A six-channel color/NIR image sensor was designed, mimicking the mantis shrimp's visual system.
  • The sensor integrates vertically stacked silicon photodetectors and pixelated spectral filters.
  • The system was tested in mice models with prostate tumors and in human breast cancer surgeries.

Main Results:

  • The sensor enabled simultaneous detection of two tumor-targeted fluorophores in mice, achieving 92% accuracy in distinguishing diseased tissue.
  • Near-infrared structured illumination accurately mapped tumor 3D topography with a 1.2-mm error.
  • Clinical trials in breast cancer patients demonstrated effective sentinel lymph node mapping using NIR fluorophores.

Conclusions:

  • The bio-inspired image sensor significantly enhances image-guided surgery capabilities.
  • The compact and flexible sensor architecture offers improved tumor visualization and surgical precision.
  • This technology holds promise for improving patient outcomes in cancer surgery.