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[Design of Intelligent Interface Based on Cytocompatible Polymers for Control on Cell Function].

Tomohiro Konno1

  • 1Graduate School of Pharmaceutical Sciences, Tohoku University.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|May 6, 2021
PubMed
Summary
This summary is machine-generated.

This study designed bioinspired phospholipid polymers for biomedical uses. These polymers demonstrate excellent cytocompatibility, drug solubilization, and form hydrogels for cell engineering applications.

Keywords:
biointerfacephospholipid polymerphotochromic polymerpolymer biomaterialsolubilizing reagentspontenous hydrogel

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Biomedical Engineering

Background:

  • 2-Methacryloyloxyehtyl phosphorylcholine (MPC) is a phospholipid polymer with applications in medical devices.
  • MPC is a methacrylate monomer copolymerizable with vinyl monomers via radical polymerization.
  • Water-solubility of MPC polymers is tunable by molecular composition and weight.

Purpose of the Study:

  • Design bioinspired polymeric biomaterials with excellent cytocompatibility.
  • Develop water-soluble MPC polymers for drug solubilization and delivery.
  • Create novel hydrogels from MPC polymers for cell immobilization and engineering.

Main Methods:

  • Copolymerization of MPC with n-butyl methacrylate to create PMB for drug solubilization.
  • Evaluation of cytotoxicity and cellular/tissue penetration of drug-loaded phospholipid polymers.
  • Formation of reversible polymeric hydrogels using MPC polymers with phenylboronic acid moieties and polyol compounds.

Main Results:

  • Phospholipid polymers exhibited low cytotoxicity.
  • Solubilized drugs effectively penetrated cells and surrounding tissues.
  • Water-soluble MPC polymers formed spontaneous, reversible hydrogels with polyols, suitable as artificial extracellular matrices.

Conclusions:

  • Bioinspired MPC-based polymeric biomaterials offer excellent cytocompatibility and drug delivery capabilities.
  • Reversible hydrogels derived from MPC polymers show promise for cell immobilization and engineering.
  • Intelligent polymeric biomaterials represent innovative techniques for pharmaceutical and life science applications.