Related Experiment Video

Updated: Nov 6, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.4K

Giant cell myocarditis

Naga Vaishnavi Gadela1, Anand Muthu Krishnan2, Osama Mukarram3

  • 1Department of Internal Medicine, University of Connecticut, Farmington, Connecticut.

Proceedings (Baylor University. Medical Center)
|May 6, 2021
PubMed

Insights

Giant cell myocarditis (GCM) is a severe heart condition requiring early diagnosis for better outcomes. Prompt immunosuppression can improve survival, but recurrence after heart transplant is a concern.

Area of Science:

  • Cardiology
  • Immunology
  • Pathology

Background:

  • Giant cell myocarditis (GCM) is a rare, aggressive cardiac disease.
  • It typically affects young, healthy adults, leading to rapid heart failure.
  • Without treatment, median survival is only three months.

Observation:

  • This case highlights GCM presenting with conduction abnormalities and acute heart failure.
  • Giant cell myocarditis requires prompt diagnosis and intervention.
  • Cyclosporine-based immunosuppression can improve transplant-free survival.

Findings:

  • Early diagnosis and treatment are critical for improving outcomes in GCM.
  • While heart transplantation is an option, GCM can recur in 25% of cases.
  • This case underscores the challenges in managing GCM, including potential recurrence.

Implications:

  • This case emphasizes the need for heightened awareness of GCM among clinicians.
  • Further research into optimal GCM treatment strategies and prevention of recurrence is warranted.
  • Understanding GCM's presentation is key for timely intervention and improved patient prognosis.

Keywords:
Cardiomyopathygiant cell myocarditisheart transplantationimmunosuppressive regimenventricular arrhythmias

More Related Videos

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.8K
Isolation and Identification of Extravascular Immune Cells of the Heart08:24

Isolation and Identification of Extravascular Immune Cells of the Heart

Published on: August 23, 2018

13.5K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
128
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
71
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
117
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
45
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
78
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
177