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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Proliferative Glomerulonephritis: Risk Factor for Hypertension in Lupus
Mansour Mbengue1, Motula Latou Lot2, Seynabou Diagne3
1Department of Nephrology, Dalal Jamm University Hospital, Dakar, Senegal.
International Journal of Hypertension
|May 6, 2021
Summary
Hypertension is prevalent in lupus nephritis, affecting 43.75% of patients. Proliferative glomerulonephritis significantly increases the risk of developing high blood pressure in these individuals.
Area of Science:
- Nephrology
- Rheumatology
- Cardiology
Background:
- Hypertension is frequently observed in patients with Systemic Lupus Erythematosus (SLE), with prevalence rates up to 74%.
- The incidence of hypertension in SLE patients correlates with the severity of kidney damage, particularly lupus nephritis.
- Kidney damage in lupus nephritis can exacerbate or contribute to the development of hypertension.
Purpose of the Study:
- To determine the prevalence of hypertension in patients diagnosed with lupus nephritis.
- To investigate the association between proliferative glomerulonephritis and the presence of hypertension in lupus nephritis.
Main Methods:
- A case-control study was conducted using medical records from the nephrology department of Aristide Le Dantec University Hospital.
- Data from 64 lupus nephritis patients over a 10-year period (January 2007 - December 2016) were analyzed.
- Prevalence of hypertension and its correlation with lupus nephritis class, specifically proliferative glomerulonephritis, were assessed.
Main Results:
- The hospital prevalence of hypertension among lupus nephritis patients was 43.75% (28 out of 64 patients).
- The mean age of patients was 30.64 years, with a predominance of women (24 women, 4 men).
- Hypertension was significantly associated with proliferative glomerulonephritis (odds ratio, 7.45; 95% CI, 1.9 to 29.1; p=0.002).
Conclusions:
- Hypertension is a common comorbidity in lupus nephritis.
- The presence of proliferative glomerulonephritis is identified as a significant risk factor for developing arterial hypertension in lupus nephritis patients.
- Regular screening and effective management of hypertension are crucial for preventing the progression of chronic kidney disease in individuals with lupus.
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