Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Mutations00:36

Viral Mutations

36.7K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
36.7K
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

638
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
638
Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

644
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
644

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: A composite lateral flow test substrate by capillary deposition of cellulose on synthetic paper.

RSC advances·2026
Same author

Tumor-draining lymph nodes shape the tumor microenvironment through enrichment of tumor-reactive effector-exhausted CD8<sup>+</sup> T cells.

Signal transduction and targeted therapy·2026
Same author

Novel strategies to overcome the blood-brain barrier in triple-negative breast cancer brain metastases.

The Lancet. Oncology·2026
Same author

A composite lateral flow test substrate by capillary deposition of cellulose on synthetic paper.

RSC advances·2026
Same author

OSTE Superhydrophobic Synthetic Paper (SUSP) with Superior Plastron Stability by Capillary Effect.

Small methods·2026
Same author

Unmet supportive care needs of head and neck cancer survivors: A scoping review.

PloS one·2026

Related Experiment Video

Updated: Nov 6, 2025

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.2K

AXL, an Important Host Factor for DENV and ZIKV Replication.

Shengda Xie1, Huiru Zhang1, Zhenjie Liang1

  • 1Ministry of Education (MOE) Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

Frontiers in Cellular and Infection Microbiology
|May 6, 2021
PubMed
Summary

Flaviviruses like Zika (ZIKV) and Dengue (DENV) use the AXL receptor for host cell entry. Understanding this interaction is key to developing new antiviral therapies against these global health threats.

Keywords:
AXLDENVZIKVinteractioninvasionphosphatidylserine (PS)

More Related Videos

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

7.1K
Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells
07:53

Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells

Published on: January 18, 2019

9.0K

Related Experiment Videos

Last Updated: Nov 6, 2025

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.2K
Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

7.1K
Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells
07:53

Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells

Published on: January 18, 2019

9.0K

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Flaviviruses, including Zika virus (ZIKV) and Dengue virus (DENV), pose significant global health risks, causing widespread outbreaks.
  • These enveloped viruses rely on host cell factors for replication, with the phosphatidylserine (PS) receptor AXL identified as a potential entry mediator.

Purpose of the Study:

  • To review the molecular structures of ZIKV and DENV.
  • To elucidate the interaction mechanisms between flaviviruses and the AXL receptor during host cell invasion.

Main Methods:

  • Literature review focusing on molecular virology and cell biology.
  • Analysis of structural data and experimental findings on flavivirus-host interactions.

Main Results:

  • Detailed discussion of ZIKV and DENV molecular structures.
  • Explanation of how these viruses engage with AXL to facilitate entry into host cells.

Conclusions:

  • A deeper comprehension of the flavivirus-AXL molecular interplay is crucial.
  • This knowledge will advance understanding of viral infection and aid in developing novel anti-flavivirus therapeutics.