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Related Experiment Videos

Nutritive expectancies mediate cholecystokinin's suppression-of-intake effect.

P M Fedorchak1, R C Bolles

  • 1Department of Psychology, University of Washington, Seattle 98195.

Behavioral Neuroscience
|June 1, 1988
PubMed
Summary

Cholecystokinin (CCK) suppresses food intake, but this effect may depend on learned caloric expectations, not just taste or texture. CCK-8 reduced consumption of an ethanol-associated flavor, but not a water-associated flavor.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Physiology

Background:

  • Previous studies on cholecystokinin (CCK) and food intake confounded physical meal characteristics with nutritive expectancies.
  • Understanding the distinct roles of sensory features versus learned expectations is crucial for CCK's satiety mechanisms.

Purpose of the Study:

  • To investigate whether cholecystokinin octapeptide (CCK-8) suppresses food intake based on learned nutritive expectations or physical meal properties.
  • To isolate the impact of caloric expectancies from unconditioned stimulus features on CCK's satiety effect.

Main Methods:

  • Rats were trained to associate distinct flavors with either caloric (ethanol) or non-caloric (water) solutions over 12 days.
  • A preference test was conducted, followed by injections of CCK-8 or saline.

Related Experiment Videos

  • Consumption of the ethanol-associated flavor (Ef) versus the water-associated flavor (Wf) was measured post-injection.

    • Main Results:

    • Rats developed a preference for the ethanol-associated flavor (Ef) over the water-associated flavor (Wf).
    • CCK-8 administration significantly suppressed the consumption of the Ef.
    • CCK-8 did not affect the intake of the Wf.

    Conclusions:

    • CCK-8's suppression of food intake appears to be mediated by learned nutritive expectations rather than the intrinsic physical characteristics of the food.
    • These findings highlight the role of associative learning in CCK-mediated satiety signals.