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How Protein Methylation Regulates Steroid Receptor Function.
Lucie Malbeteau1,2,3, Ha Thuy Pham1,2,3, Louisane Eve1,2,3
1Université de Lyon, F-69000 Lyon, France.
Endocrine Reviews
|May 6, 2021
Summary
Methylation is emerging as a key regulator of steroid receptors (SRs), influencing vital physiological functions and various diseases. Understanding these methylation events offers new therapeutic strategies for SR-related pathologies.
Area of Science:
- Molecular Biology
- Cellular Signaling
- Endocrinology
Background:
- Steroid receptors (SRs) are crucial nuclear hormonal receptors regulating essential physiological processes like development and metabolism.
- Dysregulation of SR signaling is linked to numerous pathologies.
- Post-translational modifications (PTMs) finely control SR activity, with phosphorylation being extensively studied.
Purpose of the Study:
- To provide an overview of methylation and demethylation events in SR regulation.
- To explore the functional effects and biological consequences of SR methylation.
- To highlight the therapeutic potential of targeting SR methylation.
Main Methods:
- Literature review of studies on SR methylation and demethylation.
- Analysis of the role of protein methyltransferases in SR function.
- Examination of the association between SR methylation and various diseases.
Main Results:
- Methylation is increasingly recognized as a significant regulator of SRs, complementing phosphorylation.
- Protein methyltransferases, involved in diverse functions and pathologies, also impact SR activity.
- Aberrant SR methylation is implicated in inflammation, cardiovascular and neuronal disorders, and cancer.
Conclusions:
- SR methylation/demethylation events play critical roles in both normal physiology and disease pathogenesis.
- A comprehensive understanding of SR methylation landscape can reveal novel regulatory mechanisms.
- Targeting protein methyltransferases offers promising therapeutic avenues for SR-related diseases.
Keywords:
ARERαGRPRcoregulatorslysine methyltransferasesmethylationprotein arginine methyltransferasesprotein demethylasessteroid receptorsMore Related Videos
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