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The action spectrum in quinine photosensitivity
B L Diffey1, P M Farr, S J Adams
1Regional Medical Physics Department, Dryburn Hospital, Durham, U.K.
The British Journal of Dermatology
|May 1, 1988
Summary
This study investigated ultraviolet erythema in elderly patients taking quinine. The action spectrum matched quinine absorption, highlighting the need for broad-spectrum sunscreens to prevent photosensitivity.
Area of Science:
- Photodermatology
- Pharmacology
- Spectroscopy
Background:
- Quinine sulfate is used for nocturnal leg cramps.
- Photosensitive eruptions can be triggered by medications.
- Ultraviolet (UV) radiation causes skin damage, including erythema.
Purpose of the Study:
- To determine the action spectrum for 24-hour ultraviolet erythema in patients taking quinine sulfate.
- To compare the in vivo action spectrum with the absorption spectrum of quinine.
- To assess the photoprotection efficacy of sunscreens against quinine-induced photosensitivity.
Main Methods:
- Studied three elderly patients with photosensitive eruptions taking quinine sulfate.
- Measured the in vivo action spectrum for erythema.
- Analyzed the absorption spectrum of quinine.
- Calculated the required photoprotection based on action spectra and sunlight spectrum.
Main Results:
- The in vivo action spectrum for erythema in patients correlated with quinine's absorption spectrum.
- The action spectrum extended from approximately 370 nm to 300 nm.
- Adequate photoprotection necessitates broad-spectrum sunscreens.
Conclusions:
- Quinine photosensitivity is linked to its absorption spectrum.
- UV wavelengths from 300 nm to 370 nm are critical for quinine-induced erythema.
- Broad-spectrum sunscreens are essential for managing quinine photosensitivity.