Related Experiment Video
Updated: Nov 6, 2025
09:02
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
12.1K
Palliative chemotherapy for advanced gallbladder cancer.
Gonzalo A Bravo-Soto1, Rocío Brañes2, José Peña3
1Proyecto Epistemonikos, Santiago, Chile; Centro Evidencia UC, Facultad de Medicina,Pontificia Universidad Católica de Chile, Santiago, Chile; Cochrane Collaboration.
Medwave
|May 6, 2021
Summary
Palliative chemotherapy may improve survival for advanced gallbladder cancer patients but likely increases adverse effects. A new systematic review is needed due to identified errors and new evidence.
Area of Science:
- Oncology
- Gastroenterology
- Clinical Trials
Background:
- Gallbladder cancer is the most frequent biliary tract malignancy.
- Limited therapeutic options exist for advanced stages.
- Palliative chemotherapy is being explored as a potential treatment.
Purpose of the Study:
- To systematically review the efficacy and safety of palliative chemotherapy for advanced gallbladder cancer.
- To synthesize evidence from existing systematic reviews and primary studies.
- To identify gaps and limitations in current research.
Main Methods:
- Conducted a comprehensive search of the Epistemonikos database, encompassing multiple health information sources.
- Extracted data from systematic reviews and reanalyzed primary study data.
- Performed a meta-analysis and generated a GRADE-based summary of findings.
Main Results:
- Identified two systematic reviews, including one randomized trial.
- Palliative chemotherapy may enhance survival in advanced gallbladder cancer.
- Palliative chemotherapy is associated with an probable increase in adverse effects.
Conclusions:
- Palliative chemotherapy shows potential for improving survival in advanced gallbladder cancer.
- Increased adverse effects are a likely consequence of palliative chemotherapy.
- A new systematic review is crucial due to methodological flaws and emerging evidence.
More Related Videos
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
158
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
158
01:17Gallbladder
1.3K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
1.3K
02:57Targeted Cancer Therapies
8.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.0K
01:26Diseases of the Liver and Gallbladder
1.5K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.5K
02:50Combination Therapies and Personalized Medicine
5.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.4K
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
414
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
414