Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

116
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
116
Lethal Alleles02:41

Lethal Alleles

16.9K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
16.9K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

2.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.4K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

117
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
117
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

477
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
477
Anorexia Nervosa01:28

Anorexia Nervosa

347
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
347

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).

ESMO open·2025
Same author

The combination of hyaluronic acid and collagenase in the treatment of skin ulcers: an open, multicenter clinical study assessing safety and tolerability of Bionect Start®.

European review for medical and pharmacological sciences·2024
Same author

Juvenile xanthogranuloma in neurofibromatosis type 1. Prevalence and possible correlation with lymphoproliferative diseases: experience of a single center and review of the literature.

La Clinica terapeutica·2022
Same author

Tumors in patients with neurofibromatosis type 1: a single- center retrospective study.

La Clinica terapeutica·2022
Same author

COVID-19 cutaneous manifestations in pediatric patients: 24 multisystem inflammatory syndrome in children and six Kawasaki disease cases.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Radiotherapy-induced subclinical skin changes revealed by dynamic optical coherence tomography: a case-controlled pilot study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Related Experiment Video

Updated: Nov 6, 2025

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
06:52

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

54.1K

Madelung's disease. Two case reports with pseudoathletic appearance.

E Miraglia1, E Moliterni1, C Iacovino1

  • 1Dermatologic Clinic, "Sapienza" University of Rome, Rome, Italy.

La Clinica Terapeutica
|May 6, 2021
PubMed
Summary

Madelung's disease, a rare condition of symmetrical adipose tissue, affects middle-aged men, often linked to alcoholism. Early diagnosis is crucial due to its unusual presentations.

Keywords:
Launois-Bensaude syndromeMadelung’s diseasebenign sym-metric lipomatosiscutaneous lipomatosismultiple symmetric lipomatosis

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.8K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.7K

Related Experiment Videos

Last Updated: Nov 6, 2025

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
06:52

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

54.1K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.8K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.7K

Area of Science:

  • Endocrinology
  • Dermatology
  • Metabolic Disorders

Background:

  • Madelung's disease is a rare syndrome characterized by symmetrical, unencapsulated adipose tissue masses.
  • It predominantly affects middle-aged men with a history of alcoholism, particularly those of Mediterranean origin.
  • The exact pathogenesis of Madelung's disease remains unknown.

Observation:

  • This report details two cases of Madelung's disease with unusual clinical presentations.
  • The patients' unique symptoms highlight the diagnostic challenges associated with this rare condition.
  • Clinical history and physical examination are the primary methods for diagnosing Madelung's disease.

Findings:

  • The cases presented unusual manifestations of Madelung's disease, differing from typical presentations.
  • Analysis of these cases may offer insights into the varied clinical spectrum of the disease.
  • The symmetrical distribution of adipose tissue was a key diagnostic feature in both cases.

Implications:

  • Emphasizes the importance of considering Madelung's disease even with atypical symptoms.
  • Highlights the need for thorough clinical evaluation in patients with unexplained adipose tissue accumulation.
  • Early diagnosis of Madelung's disease can potentially lead to better patient management and outcomes.