CeLaVi: an interactive cell lineage visualization tool
Irepan Salvador-Martínez1, Marco Grillo2,3, Michalis Averof2,3
1Centre for Life's Origins and Evolution, Department of Genetics Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK.
Nucleic Acids Research
|May 6, 2021
Summary
CeLaVi is a new web-based tool that visualizes cell lineages and their spatial distribution. It helps researchers explore complex cell division data, integrating lineage with cell identity and properties for better understanding.
Area of Science:
- Developmental Biology
- Computational Biology
- Bioinformatics
Background:
- Reconstructing cell lineages is crucial for understanding development and disease.
- Integrating lineage data with spatial and identity information presents a significant challenge.
- Existing tools lack intuitive visualization for complex cell lineage data.
Purpose of the Study:
- To introduce CeLaVi, a novel web-based visualization tool.
- To enable intuitive exploration and interpretation of integrated cell lineage data.
- To facilitate the analysis of cell divisions, spatial distribution, and cell properties.
Main Methods:
- Development of a web-based platform for interactive visualization.
- Implementation of features for navigating cell lineage trees.
- Integration of 3D spatial viewers with lineage data and cell properties (e.g., gene expression).
Main Results:
- CeLaVi allows users to explore cell lineage trees and visualize spatial clone distributions.
- The tool enables coloring cells by lineage relationships and visualizing cell properties in 3D.
- Demonstrated utility with four diverse example datasets, showcasing CeLaVi's capabilities.
Conclusions:
- CeLaVi provides an effective solution for visualizing and interacting with complex cell lineage data.
- The tool facilitates the integration of lineage, spatial, and cell identity information.
- CeLaVi is a valuable resource for researchers in developmental biology and related fields.
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