Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders

Area of Science:

• Ophthalmology
• Dry Eye Disease Research
• Ocular Surface Therapeutics

Background:

• Cataract surgery can lead to post-operative discomfort and dry eye symptoms.
• Maintaining ocular surface health and tear film stability is crucial for patient recovery.

Purpose of the Study:

• To evaluate the efficacy of trehalose/sodium hyaluronate eye drops.
• To assess their impact on post-operative discomfort and tear film stability in cataract surgery patients.

Main Methods:

• A prospective, randomized, open-label study compared trehalose/sodium hyaluronate eye drops with saline.
• Key metrics included tear breakup time (TBUT), Schirmer test, dry eye symptoms, corneal fluorescein staining (CFS), and OSDI scores.
• Evaluations were conducted pre-operatively and at 2 and 4 weeks post-surgery.

Main Results:

• Trehalose/sodium hyaluronate group showed increased TBUT and improved Schirmer test and CFS scores at 4 weeks.
• Significant improvements in foreign body sensation, puncture sensation, and OSDI scores were noted in the trehalose/sodium hyaluronate group.
• The trehalose/sodium hyaluronate group demonstrated superior outcomes in tear film stability and symptom relief compared to the saline group.

Conclusions:

• Trehalose/sodium hyaluronate eye drops are effective in managing post-operative dry eye.
• The drops significantly reduce dry eye signs and symptoms, improving tear film stability.
• This formulation offers a beneficial therapeutic option for patients undergoing cataract surgery.