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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia
Keziban Dogan1, Alev Kural2, Yasin Oztoprak1
1University of Health Sciences, Bakirköy Dr. Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups.Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not.Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.
Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups.Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not.Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.
