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Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in
Il Young Kim1,2, Byung Min Ye1,2, Min Jeong Kim1,2
1Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Insights
Serum uric acid (SUA) predicts left ventricular hypertrophy (LVH) and diastolic dysfunction (LVDD) in chronic kidney disease (CKD) patients. Higher SUA levels may indicate increased risk for these cardiac conditions.
Area of Science:
- Cardiology
- Nephrology
- Biochemistry
Background:
- Serum uric acid (SUA) association with left ventricular hypertrophy (LVH) and diastolic dysfunction (LVDD) is known.
- This relationship is not well-defined in patients with chronic kidney disease (CKD).
Purpose of the Study:
- To investigate the association between SUA levels and LVH/LVDD in pre-dialysis CKD patients.
- To identify SUA as a potential biomarker for cardiac abnormalities in CKD.
Main Methods:
- Cross-sectional study of 1025 pre-dialysis CKD patients with preserved systolic function.
- Echocardiography and tissue Doppler imaging used to assess LVH and LVDD.
- Univariable and multivariable logistic regression analyses performed.
Main Results:
- SUA was an independent predictor of LVH (OR: 1.40) and LVDD (OR: 1.93) in multivariable analysis.
- Age, systolic blood pressure, PTH, and left atrial volume index also predicted LVH.
- Systolic blood pressure and left atrial volume index predicted LVDD.
- Optimal SUA cutoffs for LVH and LVDD were ≥ 7.5 mg/dL and ≥ 6.3 mg/dL, respectively.
Conclusions:
- SUA is an independent predictor of LVH and LVDD in CKD patients.
- SUA may serve as a valuable biomarker for detecting cardiac abnormalities in this population.
Background:
The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). However, this association remains unclear in patients with chronic kidney disease (CKD).
Methods:
A total of 1025 patients with pre-dialysis CKD with preserved left ventricular systolic function were enrolled in this cross-sectional study. The LVH and LVDD were assessed using two-dimensional echocardiography and tissue Doppler imaging. The associations of LVH/LVDD with clinical and laboratory variables were investigated using univariable and multivariable logistic regression analyses.
Results:
In a multivariable analysis, the SUA level was an independent predictor of LVH (odds ratio [OR]: 1.40, 95% confidence interval [CI]: 1.31-1.50, P < 0.001). In addition, patient age, systolic blood pressure, intact parathyroid hormone levels, and left atrial volume index levels were independent predictors of LVH. The SUA level was also an independent predictor of LVDD (OR: 1.93, 95% CI: 1.53-2.43, P < 0.001). Furthermore, systolic blood pressure and left atrial volume index levels were an independent predictor of LVDD. Receiver-operating characteristic curve analysis showed that the best cutoff values of SUA levels for identifying LVH and LVDD were ≥ 7.5 mg/dL and ≥ 6.3 mg/dL, respectively.
Conclusion:
The SUA level was an independent predictor of LVD and LVDD in patients with CKD, suggesting that SUA could be a biomarker for LVH and LVDD.
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