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Published on: March 15, 2022
Future stroke risk in the chronic phase of post-percutaneous coronary intervention
Shinsuke Muraoka1, Daiki Somiya1, Aoi Ebata1
1Department of Neurosurgery, Tosei General Hospital, Aichi, Japan.
Insights
Cerebrovascular events (CVEs) like stroke occur in 11.7% of patients after percutaneous coronary intervention (PCI). Coronary artery calcification (CAC) sites can predict future CVEs risk after PCI.
Area of Science:
- Cardiology
- Neurology
- Radiology
Background:
- Percutaneous coronary intervention (PCI) is a common procedure for coronary syndromes.
- Stroke is a significant complication during PCI, but its incidence in the chronic phase is not well understood.
Purpose of the Study:
- To investigate the prevalence of cerebrovascular events (CVEs) after PCI in the chronic phase.
- To evaluate a simple coronary artery calcification (CAC) scoring method for predicting future CVEs.
Main Methods:
- Prospective observational study of 171 patients who underwent PCI.
- Follow-up for a median of 33 months to record cerebral infarction onset.
- Analysis of coronary artery calcification (CAC) and cervical internal carotid artery stenosis.
Main Results:
- Cerebral infarction occurred in 11.7% of patients.
- Increased CAC sites (p=0.009) and post-PCI status for chronic coronary syndrome (p=0.049) were associated with CVEs.
- A CAC site cutoff of 4.5 predicted future CVEs.
Conclusions:
- A simple CAC evaluation method can predict future CVEs risk after PCI.
- This method may be clinically applicable for risk stratification in patients undergoing PCI.
Abstract:
A percutaneous coronary intervention (PCI) is widely performed for acute coronary syndromes or chronic coronary syndromes. Periprocedural stroke is a clinically significant complication during PCI. The incidence of cerebrovascular events (CVEs) after PCI in the chronic phase is obscure. This study aimed to investigate the prevalence of CVEs after PCI in the chronic phase and evaluate the usefulness of a simple coronary artery calcification (CAC) evaluation method. This prospective observational study included 179 patients who underwent PCI between January 2016 and December 2018. The incidence of cerebral infarction was examined from one month after PCI to December 2019. In total, 171 individuals (134 men; mean age, 69.8 ± 9.8 years) were recruited. During a median follow-up period of 33 months, the onset of cerebral infarction was observed in 20 individuals (11.7%). More CAC sites (p = 0.009) and post-PCI for the chronic coronary syndrome (p = 0.049) showed a significant association with future CVEs. There was no significant cervical internal carotid artery stenosis for patients who occurred CVEs. The cutoff value for the number of CAC sites for predicting future CVEs was 4.5. The new and easy method accurately reflected future CVEs risk and may be clinically applicable.
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