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The peripheral and core regions of virus-host network of COVID-19

Bingbo Wang1, Xianan Dong1, Jie Hu1

  • 1School of Computer Science and Technology, Xidian University, Xi'an 710071, China.

Briefings in Bioinformatics
|May 6, 2021
PubMed

Insights

This study reveals the distinct core and periphery regions within the virus-host network (VHN) caused by SARS-CoV-2. Understanding this network aids in identifying COVID-19 comorbidities and potential drug repurposing strategies.

Area of Science:

  • Systems biology
  • Virology
  • Network medicine

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has had a global impact, yet the molecular mechanisms of infection are not fully understood.
  • Analyzing the human interactome provides a framework for understanding virus-host interactions.

Purpose of the Study:

  • To investigate the molecular perturbations induced by SARS-CoV-2 infection using an omnigenic perspective.
  • To identify and characterize the core and peripheral regions of the virus-host network (VHN).
  • To explore the utility of the VHN periphery in identifying comorbidities and drug repurposing candidates for COVID-19.

Main Methods:

  • Analysis of the human interactome to map the SARS-CoV-2 perturbed neighborhood.
  • Identification of core and peripheral regions within the virus-host network (VHN).
  • Development of a "flower model" based on peripheral regions for comparative disease analysis.

Main Results:

  • SARS-CoV-2 infection creates a significantly connected VHN with a distinct core of highly perturbed proteins and a larger, less perturbed periphery.
  • The periphery of the VHN is crucial for identifying COVID-19 comorbidities and potential drug repurposing candidates.
  • The "flower model" demonstrated correlations between COVID-19, SARS, and H1N1 in functional pathways and therapeutic targets.

Conclusions:

  • The periphery-core pattern of the VHN offers insights into SARS-CoV-2 protein interactions.
  • This network-based approach can facilitate the discovery of therapeutic drugs for COVID-19 and related diseases.
Keywords:
COVID-19SARS-CoV-2disease moduleomnigenicvirus-host network

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