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Updated: Nov 6, 2025
An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
Published on: February 5, 2015
The astrocyte LAMP lights a T cell TRAIL of death
1Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany; International PhD Program (IPP) of the Institute for Molecular Medicine (IMB) Mainz, Mainz, Germany.
Abstract:
In a recent issue of Nature, Sanmarco et al. reveal a novel mechanism by which astrocytes maintain an anti-inflammatory state in the central nervous system (CNS). IFNγ released by gut-licensed meningeal NK cells was found to induce TRAIL expression on astrocytes, causing effector T cell apoptosis.
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