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Updated: Nov 6, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Dimeric clerodane diterpenoids and antiviral constituents of Dodonaea viscosa
Xiao-Tong Zhao1, Chun Lei1, Jin-Qiu You1
1School of Pharmacy, Fudan University, Shanghai 201203, China.
Abstract:
Three unprecedented dimeric clerodane diterpenoids, dodovisdimers A-C (1-3), along with six known clerodane monomers (4-9), were isolated from Dodonaea viscosa. Compounds 1-3 may be biosynthetically formed via an intermolecular Diels-Alder [4+2] cycloaddition between the coexisting monomers 4-7. The structures of these clerodanes were characterized by spectroscopic techniques, X-ray crystallographic study, and ECD calculations. Some isolates exerted antiviral effects on human influenza A virus (H3N2) in vitro.
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