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Real-world analytical and clinical evaluation of the Siemens Atellica® immunoassay for plasma neurofilament light chain in multiple sclerosis.

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Interplay Between Cognitive and Bowel/Bladder Function in Multiple Sclerosis.

Antonio Carotenuto1, Teresa Costabile1, Marcello Moccia1

  • 1Department of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.

International Neurourology Journal
|May 6, 2021
PubMed
Summary
This summary is machine-generated.

Bowel/bladder dysfunction affects nearly half of multiple sclerosis (MS) patients and is linked to cognitive decline. Lower Symbol Digit Modality Test scores in MS patients may indicate underlying bowel/bladder issues.

Keywords:
BladderBowelCognitionDisabilityPatient-Reported Outcome

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Area of Science:

  • Neurology
  • Gastroenterology
  • Urology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Bowel and bladder dysfunction are common but often underreported symptoms in MS.
  • The relationship between these dysfunctions and cognitive impairment in MS requires further investigation.

Purpose of the Study:

  • To determine the prevalence of bowel/bladder dysfunction in multiple sclerosis (MS) patients.
  • To explore the association between bowel/bladder dysfunction and cognitive impairment in MS.

Main Methods:

  • Prospective enrollment of 150 MS patients.
  • Assessment using the Symbol Digit Modality Test (SDMT) for cognition, Neurogenic Bowel Dysfunction Score (NBDS), and Actionable Bladder Symptom Screening Tool (ABSST).
  • Hierarchical regression models analyzed associations between cognitive function (SDMT) and bowel/bladder dysfunction (NBDS, ABSST), controlling for demographics and physical disability.

Main Results:

  • A high prevalence of bowel/bladder deficits was observed (44.7%), with 17.3% experiencing bowel deficits and 40% experiencing bladder deficits.
  • Both total NBDS and ABSST scores showed a significant correlation with SDMT scores (P<0.001 and P=0.04, respectively), indicating an association between dysfunction and cognitive impairment.
  • These correlations persisted after adjusting for demographic features and physical disability.

Conclusions:

  • Bowel/bladder disorders are prevalent in multiple sclerosis and contribute to the overall physical and cognitive disability burden.
  • The Symbol Digit Modality Test (SDMT), commonly used in clinical settings, can serve as an indicator for potential bowel/bladder dysfunction in MS patients.
  • Routine assessment of cognitive function using SDMT may prompt further investigation into bowel/bladder issues due to their interconnectedness.