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Sebaceous carcinoma arising from sebaceoma.

Da Woon Lee¹, Si Hyun Kwak¹, Jun Hyuk Kim¹

¹Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.

Archives of Craniofacial Surgery

|May 7, 2021

Summary

This report details a rare sebaceous carcinoma arising from a sebaceoma, highlighting the potential for malignant transformation of benign adnexal tumors. Deep biopsies are crucial for accurate diagnosis of suspected skin cancers.

Keywords:

Adnexal and skin appendage neoplasms Benign neoplasms Carcinoma, skin appendage

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Area of Science:

Dermatopathology
Oncology

Background:

Sebaceous neoplasms are uncommon adnexal tumors posing diagnostic challenges.
Sebaceous carcinoma co-occurring with sebaceoma is exceptionally rare, with only four prior cases documented.

Observation:

A case of sebaceous carcinoma arising from a sebaceoma presented as a solitary posterior neck nodule.
Immunohistochemical analysis revealed strong positivity for epithelial membrane antigen and p53 in tumor cells.

Findings:

The lesion exhibited distinct benign (sebaceoma) and malignant (sebaceous carcinoma) components, suggesting malignant transformation.
The benign component displayed characteristic histopathological features of sebaceoma.

Implications:

Adnexal carcinomas may develop through de novo genesis or malignant transformation of benign precursors.
Superficial biopsies can be misleading; deep biopsies are essential when clinical suspicion of malignancy exists.