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Updated: Nov 6, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
[Refractory pulmonary edema under ECMO: Is there a place for Rashkind atrioseptotomy?]
Hydrostatic pulmonary edema is a serious complication of extracorporeal membrane oxygenation (ECMO). The Rashkind technique can be a viable option for left ventricle unloading and improving hypoxemia in select patients.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Intensive Care Medicine
Background:
- Hydrostatic pulmonary edema is a known complication of venoarterial extracorporeal membrane oxygenation (VA-ECMO).
- It arises from increased left ventricle afterload due to retrograde aortic blood flow.
- Current left ventricle venting strategies include intra-aortic balloon pump, Impella, surgical cannulation, and Rashkind atrial septostomy.
Purpose of the Study:
- To report two cases of hydrostatic pulmonary edema in patients undergoing VA-ECMO.
- To evaluate the feasibility and efficacy of the Rashkind technique for managing this complication.
- To highlight the importance of pre-procedural assessment for potential contraindications.
Main Methods:
- Case report of two patients experiencing hydrostatic pulmonary edema during VA-ECMO.
- Application of the Rashkind technique in the first case for left ventricle unloading.
- Transesophageal echocardiography in the second case to identify a left atrial thrombus preventing the Rashkind procedure.
Main Results:
- The Rashkind technique was successfully performed in the first patient, leading to improved hypoxemia and effective left ventricle unloading.
- In the second patient, transesophageal echocardiography revealed a large left atrial thrombus extending to the pulmonary veins, precluding the Rashkind maneuver and contributing to elevated hydrostatic pressure.
- These cases underscore the clinical significance and potential severity of VA-ECMO-induced pulmonary edema.
Conclusions:
- The Rashkind technique is a feasible option for managing hydrostatic pulmonary edema during VA-ECMO, offering significant left ventricle unloading and hypoxemia improvement.
- Pre-procedural transesophageal echocardiography is crucial to rule out left atrial thrombi that can impede the Rashkind procedure and exacerbate pulmonary edema.
- Early identification and management of pulmonary edema are vital for patients on VA-ECMO.
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