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Clinical course and outcome of patients with COVID-19 in Mumbai City: an observational study

Rosemarie de Souza1, Sharayu Mhatre2, Burhanuddin Qayyumi3

  • 1Department of Medicine, BYL Nair Charitable Hospital, Mumbai, India drrosemariedesouza@gmail.com.

BMJ Open
|May 7, 2021
PubMed

Insights

In Mumbai, 22.64% of hospitalized COVID-19 patients died. Older age, comorbidities, and symptoms increased mortality risk, especially in women. Treatments like hydroxychloroquine did not improve outcomes.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Mumbai experienced a high burden of COVID-19 cases in India.
  • Understanding in-hospital outcomes is crucial for managing patient care during pandemics.

Purpose of the Study:

  • To analyze the outcomes of hospitalized COVID-19 patients in Mumbai.
  • To identify factors associated with in-hospital mortality.

Main Methods:

  • An observational study was conducted using medical records of 689 COVID-19 patients admitted to Nair Hospital & TN Medical College.
  • Data collected from March 26 to May 11, 2020.
  • In-hospital mortality and the combined effect of age and comorbidity on mortality risk were assessed.

Main Results:

  • The in-hospital mortality rate was 22.64%.
  • Older age (HR 2.88), comorbidities (HR 2.56), hypertension (HR 3.19), and admission symptoms (HR 3.21) significantly increased mortality risk.
  • Combination treatments (azithromycin/hydroxychloroquine, antivirals, steroids) did not reduce mortality. The combined effect of age and comorbidity was greater in women.

Conclusions:

  • Hospitalized COVID-19 patients in Mumbai were younger and less symptomatic compared to Western countries.
  • Age and comorbidities are significant risk factors for in-hospital mortality.
  • Current combination treatments showed no benefit in reducing mortality.
Abstract

Keywords:
epidemiologypublic health

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