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Draft Genome Sequences of Three Multidrug-Resistant Staphylococcus spp. Isolated from Hospital Wastewater in Malaysia

Nurul Syazwani Ahmad Sabri1, Siti Norayuni Mohd Zulkeflle1, Nurtasbiyah Yusof1

  • 1Department of Chemical and Environmental Engineering, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia.

Microbiology Resource Announcements
|May 7, 2021
PubMed

Insights

Three Staphylococcus strains from Malaysian hospital wastewater show resistance to multiple antibiotics. These findings highlight the potential of wastewater as a reservoir for antimicrobial resistance genes in Staphylococcus species.

Area of Science:

  • Microbiology
  • Genomics
  • Environmental Science

Background:

  • Staphylococcus species are common bacteria in human and animal microbiota.
  • These bacteria can carry antimicrobial resistance (AMR) genes, posing a public health risk.
  • Hospital wastewater is a potential environment for the dissemination of resistant bacteria.

Purpose of the Study:

  • To present the draft genome sequences of Staphylococcus strains isolated from hospital wastewater.
  • To investigate the antimicrobial resistance profiles of these strains.
  • To assess the potential of hospital wastewater as a reservoir for AMR genes.

Main Methods:

  • Isolation of Staphylococcus strains from hospital wastewater samples in Malaysia.
  • Whole-genome sequencing of the identified strains.
  • Antimicrobial susceptibility testing to determine resistance patterns.

Main Results:

  • Three draft genome sequences of Staphylococcus species were obtained.
  • The isolated strains exhibited resistance to multiple antibiotics.
  • Genomic analysis likely revealed the presence of AMR genes.

Conclusions:

  • Hospital wastewater harbors Staphylococcus strains with multidrug resistance.
  • These findings underscore the importance of monitoring wastewater for AMR.
  • Further research is needed to understand the transmission dynamics of resistant Staphylococcus in healthcare settings.

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