Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

12.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.8K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

517
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
517
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.2K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.2K
Longitudinal Studies01:26

Longitudinal Studies

300
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
300
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.5K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.5K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.7K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic productive cough and inhalant occupational exposure-a study of the general population.

International archives of occupational and environmental health·2021
Same author

Occupational exposures and exacerbations of asthma and COPD-A general population study.

PloS one·2020
Same author

Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride.

Hepatology (Baltimore, Md.)·2017
Same author

Body mass index and breast cancer survival: a Mendelian randomization analysis.

International journal of epidemiology·2017
Same author

Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals.

European heart journal·2017
Same author

U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies.

European heart journal·2017
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
Same journal

ERS Statement on ultrasound guided interventions in respiratory disease.

The European respiratory journal·2026
Same journal

When symptoms and resting tests disagree in interstitial lung disease: a selective role for cardiopulmonary exercise testing.

The European respiratory journal·2026
Same journal

Clinical Practice Guideline for the diagnosis of Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD) in patients with Common Variable Immunodeficiency Disorders (CVID) - an ERS Clinical Research Collaboration.

The European respiratory journal·2026
Same journal

SARS-CoV-2 (E)-protein induces rapid TLR2-mediated T cell activation in mouse lungs revealed by intravital lung microscopy.

The European respiratory journal·2026
Same journal

Functional characterization of <b><i>KCNA5</i></b> gene variants linked to pulmonary arterial hypertension.

The European respiratory journal·2026
See all related articles

Related Experiment Video

Updated: Nov 6, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.2K

Occupational inhalant exposures and longitudinal lung function decline.

Stinna Skaaby1, Esben Meulengracht Flachs2, Peter Lange3,4,5,6

  • 1Dept of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark Stinna.skaaby@regionh.dk.

The European Respiratory Journal
|May 7, 2021
PubMed
Summary
This summary is machine-generated.

Workplace exposure to dusts, gases, and fumes did not significantly impact lung function decline in recent Danish population studies. However, past exposures may have been linked to lung function changes decades ago.

More Related Videos

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

4.5K
Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.9K

Related Experiment Videos

Last Updated: Nov 6, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.2K
Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

4.5K
Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.9K

Area of Science:

  • Occupational Health
  • Pulmonary Medicine
  • Environmental Epidemiology

Background:

  • Workplace airborne exposures are suspected contributors to lung function decline.
  • Longitudinal evidence linking occupational exposures to lung function decline is limited and inconsistent.

Purpose of the Study:

  • To investigate the association between occupational airborne exposures and lung function decline.
  • To analyze trends in this association over different time periods.

Main Methods:

  • Utilized data from two Danish general population cohorts (Copenhagen City Heart Study and Copenhagen General Population Study).
  • Assigned occupational exposure data using a job exposure matrix for a mean follow-up of 9 years.
  • Employed linear mixed-effects models to assess the association between exposure and annual decline in forced expiratory volume in 1-second (FEV1), adjusting for covariates.

Main Results:

  • Analyzed data from 16,144 individuals (mean age 48 years, 43% male).
  • No significant association was found between occupational exposure to mineral dusts, biological dusts, gases, and fumes, and FEV1 decline when exposure was dichotomized.
  • Gases and fumes exposure showed an association with FEV1 decline (-5.8 mL/unit/year) during 1976-1983, but not in 2001-2015.

Conclusions:

  • Occupational exposure to dusts, gases, and fumes was not linked to increased lung function decline in recent Danish general population cohorts.
  • Historical occupational exposures, particularly to gases and fumes, may have had a greater impact on lung function decline in earlier periods (1976-1983).