Hypergranulotic Dyskeratotic Acanthoma: Another Histologically Distinctive Acanthoma

Area of Science:

• Dermatopathology
• Histopathology
• Oncology

Background:

• Various acanthomas are classified by unique histopathological patterns.
• Hypergranulotic dyskeratotic acanthoma is a rare variant with limited reporting.
• Accurate diagnosis relies on recognizing specific histological markers.

Purpose of the Study:

• To delineate the clinical and histological features of hypergranulotic dyskeratotic acanthoma.
• To establish diagnostic criteria for this rare acanthoma.
• To differentiate it from other acanthoma subtypes.

Main Methods:

• Retrospective analysis of 18 cases diagnosed between 2012-2017 from two dermatopathology laboratories.
• Inclusion criteria based on specific histopathological findings.
• Review of clinical data including patient demographics and lesion location.

Main Results:

• The study identified 18 cases meeting inclusion criteria, predominantly affecting women (78%) with a mean age of 53.
• The thigh was the most common site of involvement.
• Consistent histopathological findings included epidermal hyperplasia, specific hyperkeratosis, diffuse hypergranulosis, and characteristic dyskeratotic keratinocytes.

Conclusions:

• Hypergranulotic dyskeratotic acanthoma exhibits repeatable histopathological findings.
• These distinctive features allow for easy differentiation from other acanthomas.
• Further research is warranted, acknowledging the limitations of a small sample size and retrospective design.