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Blood Purification Techniques, Inflammatory Mediators and Mortality in COVID-19 Patients

Seyed Mohammadreza Hashemian1, Navid Shafigh2, Golnaz Afzal3

  • 1Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Tanaffos
|May 7, 2021
PubMed

Insights

Combined hemoperfusion (HP) and continuous renal replacement therapy (CRRT) improved COVID-19 patient outcomes. This approach reduced inflammatory mediators and improved oxygenation, showing the best survival rates in a small patient group.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Nephrology

Background:

  • Inflammatory mediators play a crucial role in COVID-19 pathophysiology.
  • Acute Respiratory Distress Syndrome (ARDS) is a common complication in severe COVID-19.
  • Reducing inflammation is a potential therapeutic strategy for COVID-19.

Purpose of the Study:

  • To evaluate the impact of hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on mortality in COVID-19 patients.
  • To assess the efficacy of HP and CRRT in reducing inflammatory mediators.
  • To determine the effect of HP and CRRT on oxygenation parameters in COVID-19 patients.

Main Methods:

  • A study involving twelve COVID-19 patients with ARDS.
  • Patients were allocated to three groups: HP, CRRT, and combined HP+CRRT.
  • Primary outcome was mortality; secondary outcomes included inflammatory mediator levels and oxygenation.

Main Results:

  • The combined HP+CRRT group showed the highest survival rate (50%), followed by the HP group (50%).
  • All patients in the CRRT-only group (100%) died.
  • Improvements in oxygenation and inflammatory markers were observed in the HP+CRRT and CRRT groups, but not significantly in the HP group.

Conclusions:

  • Combined HP and CRRT demonstrated superior outcomes in reducing mortality, inflammatory mediators, and improving oxygenation in COVID-19 patients.
  • This combination therapy appears promising for managing severe COVID-19.
  • Further research is warranted to confirm the role of HP+CRRT in COVID-19 treatment.
Abstract

Keywords:
ARDSAcute respiratory distress syndromeCOVID-19Continuous renal replacement therapyCoronavirus disease 2019CytokineHemoperfusionInflammatory markerMortalityOxygenation

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