Related Experiment Video
Updated: Nov 6, 2025
Author Spotlight: Enhancing Coronary Artery Revascularization
Published on: September 15, 2023
Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent
You Chen1, Min Han2, Ying-Ying Zheng3
1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Insights
The Model for End-Stage Liver Disease (MELD) score predicts long-term mortality in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Higher MELD scores are associated with increased all-case and cardiac mortality.
Area of Science:
- Cardiology
- Hepatology
- Clinical Outcomes Research
Background:
- Coronary heart disease (CHD) involves blocked or spasming coronary arteries, with known links to liver disease.
- The relationship between the Model for End-Stage Liver Disease (MELD) score and outcomes post-percutaneous coronary intervention (PCI) remained unclear.
Purpose of the Study:
- To investigate the association between MELD score quartiles and long-term mortality in patients undergoing PCI.
- To evaluate the predictive value of the MELD score for cardiac mortality and other adverse events after PCI.
Main Methods:
- Retrospective cohort study of 5373 CHD patients who underwent PCI (2008-2016).
- Patients stratified into four groups based on MELD score quartiles.
- Primary endpoint: long-term mortality (all-case and cardiac); Secondary endpoints: bleeding, readmission, MACE, MACCE.
Main Results:
- Significant differences in all-case mortality (ACM) and cardiac mortality (CM) across MELD groups (p=0.038, p=0.027).
- No significant differences observed for MACE, MACCE, readmission, or bleeding events.
- Multivariable analysis confirmed MELD score's independent association with ACM (HR:1.57) and CM (HR:1.434) after adjusting for covariates.
Conclusions:
- The MELD score is a strong predictor of long-term mortality in CHD patients following PCI.
- Elevated MELD scores indicate a higher risk of adverse long-term outcomes, including cardiac death.
Background:
Coronary heart disease (CHD) is caused by the blockage or spasm of coronary arteries. Evidence shows that liver disease is related to CHD. However, the correlation between the Model for End-Stage Liver Disease (MELD) score and outcomes in patients after percutaneous coronary intervention (PCI) was unclear.
Method:
A retrospective cohort study involved 5373 patients with coronary heart disease after PCI was conducted from January 2008 to December 2016. Participants were classified to four groups according to the MELD score by quartiles. The primary endpoint was long-term mortality including all-case mortality (ACM) and cardiac mortality (CM). Secondary endpoints included bleeding events, readmission, major adverse cardiovascular events (MACE), major adverse cardiovascular, and cerebrovascular events (MACCE). The longest follow-up time was almost 10 years.
Results:
There were significant differences in the incidences of ACM (p=0.038) and CM (p=0.027) among the four MELD groups, but there was no significant difference in MACEs (p=0.496), MACCEs (p=0.234), readmission (p=0.684), and bleeding events (p=0.232). After adjusting the age, gender, smoking, drinking status, and diabetes by a multivariable Cox regression analysis, MELD remains independently associated with ACM (HR:1.57, 95%CI 1.052-2.354, p=0.027) and CM (HR:1.434, 95% CI 1.003-2.050, p=0.048).
Conclusion:
This study indicated that the MELD score had a strong prediction for long-term mortality in CHD patients who underwent PCI.
