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Large-Scale Production of Cardiomyocytes from Human Pluripotent Stem Cells Using a Highly Reproducible Small Molecule-Based Differentiation Protocol
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COVID-19 in Children with Congenital Heart Diseases: A Multicenter Case Series from Iran

Hassan Esmaeeli1, Mehdi Ghaderian2, Keyhan Sayadpour Zanjani3

  • 1Cardiology Department, School of Medicine, Gorgan University of Medical Sciences, Gorgan, Iran.

Case Reports in Pediatrics
|May 7, 2021
PubMed

Insights

Children with congenital heart disease (CHD) and COVID-19 face severe risks. Early treatment is crucial for better outcomes in pediatric patients with these combined conditions.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • COVID-19 poses significant risks, particularly to children with underlying conditions.
  • Diagnosing COVID-19 in children with congenital heart disease (CHD) presents challenges.
  • Differentiating viral effects from pre-existing cardiac conditions is complex for clinicians.

Observation:

  • Seven pediatric patients with CHD and COVID-19 were analyzed across three medical centers.
  • The cohort included infants and adolescents, with a median age of 9 months.
  • All patients had obstructive lesions or pulmonary hypertension; common symptoms included cough, dyspnea, and fever.

Findings:

  • Children with CHD, especially those with obstructive lesions or pulmonary hypertension, are vulnerable to severe COVID-19.
  • Two out of seven pediatric patients in the case series did not survive.

Implications:

  • Urgent treatment is vital for pediatric patients with co-occurring COVID-19 and severe cardiac conditions.
  • This highlights the need for heightened vigilance and tailored management strategies.
  • Further research is warranted to understand COVID-19's impact on pediatric cardiovascular health.
Abstract

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