Sinonasal Renal Cell-Like Adenocarcinoma

Area of Science:

• Oncology
• Otorhinolaryngology

Background:

• Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare malignant tumor.
• Its clinical course and treatment response are not well-established.

Observation:

• A case of SNRCLA in a 26-year-old male presented with headache, epistaxis, and nasal obstruction.
• Imaging revealed extensive ethmoid sinus involvement with cribriform plate extension.
• The patient underwent surgical excision and adjuvant radiotherapy, but required salvage surgery for persistent disease.

Findings:

• A literature review identified 14 previously reported SNRCLA cases.
• Common symptoms include epistaxis and nasal obstruction.
• Surgical excision was the primary treatment in most cases, with adjuvant radiotherapy used in some.
• Three cases experienced persistent or recurrent disease.

Implications:

• Surgical excision is the current mainstay for SNRCLA treatment.
• Adjuvant radiotherapy may be considered, but outcomes are variable.
• SNRCLA appears to be a low-grade tumor with no reported metastases or deaths.
• Further research is needed to establish best practices for SNRCLA management.