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FOXO3A Expression in Upper Tract Urothelial Carcinoma
Guoyao Zhang1, Wanping Shi2, Enzhao Jia3
1Department of Oncology, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China.
Frontiers in Oncology
|May 7, 2021
Summary
FOXO3A expression is decreased in upper tract urothelial carcinoma (UTUC), correlating with advanced disease and poorer survival. Low FOXO3A predicts worse overall survival and recurrence-free survival in UTUC patients.
Area of Science:
- Oncology
- Molecular Biology
- Urothelial Carcinomas
Background:
- Epidemiological studies show varied results on FOXO3A's role in carcinomas.
- The prognostic significance of FOXO3A in upper tract urothelial carcinoma (UTUC) is not well-established.
Purpose of the Study:
- To investigate the correlation between FOXO3A expression and oncological outcomes in UTUC.
- To determine if FOXO3A serves as a prognostic marker for UTUC patients.
Main Methods:
- Immunohistochemistry (IHC) was used to assess FOXO3A expression in 107 UTUC patient samples.
- Cox proportional hazard models were employed to analyze the prognostic role of FOXO3A.
Main Results:
- FOXO3A expression was significantly lower in UTUC tissues compared to controls.
- Decreased FOXO3A correlated with advanced pathologic stage, lymph node metastasis, and lymphovascular invasion.
- Low FOXO3A expression was associated with significantly shorter overall survival (OS) and recurrence-free survival (RFS) in UTUC patients.
Conclusions:
- FOXO3A expression is linked to UTUC recurrence and progression.
- FOXO3A holds potential clinical value for therapeutic targeting and prognostic assessment in UTUC.
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