[Overactive bladder pathogenetic features and choice of drug therapy]

Area of Science:

• Urology
• Neuroscience
• Pharmacology

Background:

• Founders of bladder function studies in the country.
• Nervous and humoral regulation of lower urinary tract activity.
• Cholinergic and adrenergic mediator effects.

Purpose of the Study:

• To present a clinical lecture on bladder function.
• To describe pathogenetic features of detrusor dysfunction in overactive bladder.
• To outline principles of drug therapy selection for overactive bladder.

Main Methods:

• Clinical lecture format.
• Review of scientific literature on bladder function and overactive bladder.
• Comparative analysis of M-anticholinergic drugs.

Main Results:

• Overview of historical contributions to bladder function research.
• Explanation of the complex nervous and humoral regulatory mechanisms.
• Detailed discussion on the pathophysiology of detrusor dysfunction.
• Comparative characteristics of contemporary M-anticholinergic medications.

Conclusions:

• Understanding bladder function regulation is crucial for managing detrusor dysfunction.
• Effective drug therapy for overactive bladder relies on understanding pathogenetic features.
• M-anticholinergics represent a key therapeutic option, with distinct comparative profiles.