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Magnetically driven treatments: optimizing performance by mitigation of eddy currents
Aikaterini-Rafailia Tsiapla1,2, Konstantinos Angelou1, Mavroeidis Angelakeris1,2
1School of Physics, Faculty of Sciences, Aristotle University, Thessaloniki 54124, Greece.
Nanomedicine (London, England)
|May 7, 2021
Summary
Controlling magnetic field parameters in Magnetic Particle Hyperthermia (MPH) and MRI treatments mitigates harmful eddy currents. This reduces side effects on healthy tissues while maintaining therapeutic efficacy in malignant regions.
Area of Science:
- Biomedical Engineering
- Medical Physics
- Oncology
Background:
- Eddy currents are induced in conductive tissues during Magnetic Resonance Imaging (MRI) and Magnetic Particle Hyperthermia (MPH).
- These currents can cause undesirable heating in surrounding healthy tissues, potentially leading to side effects.
- Controlling these eddy currents is crucial for optimizing the safety and efficacy of these treatments.
Purpose of the Study:
- To investigate the evolution of eddy currents in MRI and MPH.
- To propose and evaluate methods for mitigating eddy currents through control of field parameters.
- To assess the impact of mitigation strategies on therapeutic outcomes and side effects.
Main Methods:
- Simulations of typical MRI and MPH experimental setups to observe eddy current generation.
- Experimental examination of field parameter effects (frequency, amplitude, pulse duration) on eddy currents in MPH.
- Analysis of heating patterns in simulated and experimental models.
Main Results:
- Eddy currents were successfully simulated and observed in typical MRI and MPH setups.
- Tuning frequency, amplitude, and utilizing pulsed field modes significantly attenuated eddy currents.
- Undesirable heating in healthy tissues was reduced without compromising the therapeutic effect in malignant regions.
Conclusions:
- Careful control of magnetic field parameters effectively mitigates eddy currents during MPH treatments.
- This mitigation strategy enhances treatment safety by reducing side effects on healthy tissues.
- The findings support the development of more reliable and safer magnetically driven therapies.
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