Related Experiment Video

Updated: Nov 6, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.5K

Systemic immune inflammation index: a novel predictor for coronary collateral circulation

Saban Kelesoglu1, Yucel Yilmaz2, Deniz Elcık1

  • 1Department of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Perfusion
|May 7, 2021
PubMed

Insights

The Systemic Immune Inflammation Index (SII) is a new marker that predicts poor Coronary Collateral Circulation (CCC) in stable Coronary Artery Disease (CAD) patients. Higher SII levels indicate a greater likelihood of developing inadequate CCC.

Area of Science:

  • Cardiology
  • Inflammation Markers
  • Vascular Biology

Background:

  • Coronary Artery Disease (CAD) is a leading cause of mortality worldwide.
  • Coronary Collateral Circulation (CCC) plays a crucial role in mitigating ischemic damage in CAD.
  • Identifying reliable markers for predicting CCC development is essential for patient management.

Purpose of the Study:

  • To investigate the association between the Systemic Immune Inflammation Index (SII) and the formation of CCC in patients with stable CAD.
  • To evaluate SII as a potential predictor of inadequate CCC development.

Main Methods:

  • A cohort of 449 patients with stable CAD and significant coronary stenosis was analyzed.
  • Patients were categorized based on CCC status using the Rentrop score (well CCC: Rentrop 2-3; bad CCC: Rentrop 0-1).
  • The Systemic Immune Inflammation Index (SII) was calculated as platelet count × neutrophil/lymphocyte count.

Main Results:

  • Patients with inadequate CCC exhibited significantly higher levels of C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), platelets/lymphocyte ratio (PLR), and SII compared to those with well-developed CCC (p < 0.001).
  • Multivariate logistic regression identified high SII levels as an independent predictor of inadequate CCC (OR: 1.005, 95% CI: 1.003-1.006, p < 0.001).
  • Receiver Operator Characteristic (ROC) analysis determined an optimal SII cutoff of 729.8 for predicting poor CCC, with 78.4% sensitivity and 74.6% specificity (AUC = 0.833).

Conclusions:

  • The Systemic Immune Inflammation Index (SII) is a novel and independent predictor of Coronary Collateral Circulation (CCC) development in stable Coronary Artery Disease (CAD).
  • SII may serve as a valuable prognostic marker in assessing the potential for collateralization in CAD patients.
  • Further research is warranted to explore the clinical utility of SII in cardiovascular risk stratification.
Abstract

Keywords:
Rentrop gradecardiologycoronary collateral circulationstable coronary artery diseasesystemic immune inflammation index

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.7K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.2K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
128
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
581
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
65
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
299
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
71