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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Related Experiment Video

Updated: Nov 6, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Cefepime use: A need for antimicrobial stewardship.

Alexandre Meurant1, François Guérin2, Simon Le Hello3

  • 1Pharmacie centrale, Unicaen, CHU de Caen Normandie, Normandie Université, 14000 Caen, France.

Infectious Diseases Now
|May 7, 2021
PubMed
Summary

Cefepime prescriptions in a French hospital showed appropriate indications but often failed to meet all proper use criteria. Promoting optimal cefepime use is crucial given its increasing consumption and role in treatment guidelines.

Keywords:
Antimicrobial stewardshipCefepimeCephalosporinaseDrug resistanceEnterobacteriaceae

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Area of Science:

  • Infectious Diseases
  • Clinical Pharmacy
  • Antimicrobial Stewardship

Background:

  • Cefepime, a cephalosporin, has a low risk of selecting resistant mutants and aids in carbapenem conservation.
  • It is effective against challenging pathogens like Pseudomonas aeruginosa and the CESP group.
  • Evaluating cefepime prescription practices is essential for antimicrobial stewardship.

Purpose of the Study:

  • To assess the adherence to proper use criteria for cefepime prescriptions in a French teaching hospital.
  • To identify areas for improvement in cefepime prescribing patterns.

Main Methods:

  • A retrospective study analyzed 142 cefepime prescriptions over one year.
  • Criteria assessed included indication, stewardship, dosing, documentation, reevaluation, and duration.
  • Prescriptions were compared against local guidelines derived from international literature.

Main Results:

  • 97.2% of prescriptions had validated indications.
  • Treatment duration and dosage adaptation to indication/kidney function showed variable adherence (56.5%–97.2%).
  • Only 13.4% of prescriptions met all criteria for proper cefepime use.

Conclusions:

  • Despite appropriate indications, many cefepime prescriptions did not meet all proper use criteria.
  • Increased cefepime consumption necessitates enhanced promotion of its appropriate use.
  • Optimizing cefepime prescribing is vital for antimicrobial stewardship and combating resistance.