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Related Experiment Video

Updated: Nov 6, 2025

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
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Metastatic Crohn's disease: an underestimated entity.

Franziska Ickrath1, Johanna Stoevesandt1, Lena Schulmeyer1

  • 1Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|May 7, 2021
PubMed
Summary

Cutaneous metastatic Crohn's disease (MCD) is a rare skin condition. This review summarizes 264 cases, detailing clinical features, diagnosis, and treatment challenges for this Crohn's disease manifestation.

Keywords:
Crohn's diseaseclinical presentationextraintestinalmetastaticperianalskin involvementtherapy

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Area of Science:

  • Dermatology
  • Gastroenterology
  • Pathology

Background:

  • Cutaneous metastatic Crohn's disease (MCD) is a rare dermatologic manifestation.
  • Histologically defined by non-caseating granulomas in skin separate from the GI tract.
  • Distinct from contiguous skin lesions (perianal, peristomal).

Purpose of the Study:

  • To review clinical characteristics, etiopathology, histology, differential diagnoses, and treatment of MCD.
  • To summarize existing literature and present new cases.

Main Methods:

  • Systematic literature search for pediatric and adult MCD cases.
  • Inclusion of three additional case reports.

Main Results:

  • Identified and analyzed 264 published cases of MCD.
  • Summarized versatile clinical presentations, diagnostic challenges, and treatment limitations.

Conclusions:

  • MCD presents a diagnostic and therapeutic challenge due to its rarity and varied presentation.
  • Further research is needed to establish effective management strategies for MCD.