Metastatic Crohn's disease: an underestimated entity
Franziska Ickrath1, Johanna Stoevesandt1, Lena Schulmeyer1
1Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Summary
Cutaneous metastatic Crohn's disease (MCD) is a rare skin condition. This review summarizes 264 cases, detailing clinical features, diagnosis, and treatment challenges for this Crohn's disease manifestation.
Area of Science:
- Dermatology
- Gastroenterology
- Pathology
Background:
- Cutaneous metastatic Crohn's disease (MCD) is a rare dermatologic manifestation.
- Histologically defined by non-caseating granulomas in skin separate from the GI tract.
- Distinct from contiguous skin lesions (perianal, peristomal).
Purpose of the Study:
- To review clinical characteristics, etiopathology, histology, differential diagnoses, and treatment of MCD.
- To summarize existing literature and present new cases.
Main Methods:
- Systematic literature search for pediatric and adult MCD cases.
- Inclusion of three additional case reports.
Main Results:
- Identified and analyzed 264 published cases of MCD.
- Summarized versatile clinical presentations, diagnostic challenges, and treatment limitations.
Conclusions:
- MCD presents a diagnostic and therapeutic challenge due to its rarity and varied presentation.
- Further research is needed to establish effective management strategies for MCD.
Keywords:
Crohn's diseaseclinical presentationextraintestinalmetastaticperianalskin involvementtherapyMore Related Videos
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